The information of 4-Methoxyindole

4-Methoxyindole reacts with triethyl orthoformate (1a) beneath proton catalysis to crop the functionalized indoles3a–3e in assurance on the acknowledgment conditions. The advance of the electrophile takes abode regiospecifically at the 3-position of the indole2
In Abhängigkeit von den Reaktionsbedingungen reagiert 4-Methoxyindol  mit Orthoameisensäuretriethylester (1a) zu funktionalisierten Indolderivaten3a–3e. Der Angriff des Elektrophils erfolgt regiospezifisch an der 3-Position von2.Two indole compounds abandoned from beginning Chinese banknote were apparent to be mutagen precursors that yielded direct-acting mutagens on analysis with nitrite. They were articular as 4-methoxyindole-3-acetonitrile and 4-methoxy-indole-3-aldehyde. When these compounds were advised with 50 mM nitrite at pH 3.0 for 1 h at 37°C, 4-methoxyindole-3-acetonitrile induced 31 800 and 10 000 revertants of Salmonella typhimurium TA100 and TA98, respectively, per mg of mutagen forerunner in the absence of S9 mix, and 4-meth-oxyindole-3-aldehyde induced 156 900 revertants of TA100 and 26 800 revertants of TA98 per mg in the absence of S9 mix.Methoxyindole,98%; 4-methoxy-1H-indole
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