Thursday, March 29, 2012

The description of (-)-Camphoricacid


(-)-Camphoricacid ; (1S,3R)-()-Camphoric acid; (1S,3R)-1,2,2-trimethylcyclopentane-1,3-dicarboxylic acid
Camphoric acid, C10H16O4 or in Latin form Acidum camphoricum, is a white crystallisable substance obtained from the oxidation of camphor, it exists in three optically different forms; dextrorotatory one is obtained by the oxidation of dextrorotatory camphor and used in pharmaceuticals.
Camphoric acid may be prepared by oxidising camphor with nitric acid.
This acid has a mild camphor action; it is not very toxic and can be used in very large doses, up to 4 grams (60 grains), without serious effects; it is supposed to paralyse the nerve-endings in the sweat glands, and is used in the night-sweats of tuberculosis.[citation needed] It does not affect other secretions as does atropine, nor irritate the stomach like agaric acid. Camphoric acid is also employed in solution, 0.2 to 5.0 percent by weight or volume, with sufficient alcohol, as a local antiseptic to the nose, throat and bladder, among other uses, is usually administered as a powder, or in cachets, but may also be given in mixtures suspended with compound powder of tragacanth, or dissolved by the addition of diluted alcohol or a flavouring tincture. When used as an antihydrotic the dose should be given two or three hours before bedtime.
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