This report provides general information on2-Bromo-dibenzofuran
The lithiation of troticene was studied. Monolithiation of troticene at 0°C preferentially occurred at the cycloheptatrienyl (Cht) ligand,1,2 while monolithiation at room temperature preferentially occurred at the cyclopentadienyl (Cp) ligand. Dimethylsilyl-, trimethylstannyl-, diphenylphosphino-, and trimethylsilyl-derivatives were prepared in this manner. The monolithio-cycloheptatrienyl-troticene was found to be less stable at higher temperatures than the monolithio-cyclopentadienyl-troticene. Dilithiation of troticene was readily achieved using 2.5 equiv. n-butyllithium/TMEDA,3 and using an even greater excess of lithiating agent led to greater degrees of lithiation of up to 4 lithiums. Disubstituted Cp ligands are predominantly 1,3-disubstituted, while disubstituted Cht ligands are predominantly 1,4-disubstituted. Substituted troticene derivatives were also lithiated. Just like the 1-pot polylithiation, disubstituted Cp ligands are predominantly 1,3-disubstituted. However, disubstituted Cht ligands are either 1,4- or 1,3-disubstituted.
We recently reported that 3,3-dimethyl-3H-benzofuro[3,2,f][1]-benzopyran and its hydrogenated analogue are selective in vitro inhibitors of mycobacterial growth. However, their lack of in vivo activity on a murine model of Mycobacterium tuberculosis infection due to their poor bioavailability led to a structure–activity relationship investigation. We wish to report here the preparation of some structural analogues along with their biological effect on the growth of Mycobacterium smegmatis, M. tuberculosis, as well as on VERO cells for the most active compound.
Read more:2-Bromo-dibenzofuran price
No comments:
Post a Comment