Gentamicin is a member of the aminoglycoside family of antibiotics. Gentamicin is active against Enterobacteriaceae organisms including Escherichia coli, Proteus, Klebsiella, Serratia, Enterobacter, and Citrobacter.
Gentamicin is one of the few heat-stable antibiotics that remain active even after autoclaving, which makes it particularly useful in the preparation of some microbiological growth media. It is used during orthopaedic surgery when high temperatures are required for the setting of cements.
Gentamicin is a bactericidal antibiotic that works by irreversibly binding the 30S subunit of the bacterial ribosome, interrupting protein synthesis. This mechanism of action is similar to other Aminoglycosides.
CAS NO:1403-66-3
Molecular formula:C21H43N5O7
Molecular weight:477.596 g/mol
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