About Trandolapril

Trandolapril is almost white or pale yellow, slightly hygroscopic powder.The melting point is 122-123°C.It is freely soluble in glacial acetic acid. Its loss on drying is not more than 0.5% and the assay is not more than 98.0%.Its heavy metal is not more than 10ppm and residue on lgnition is not more than 0.15%.It is used for an  antihypertensive.It can also be used for an angiotensin converting enzyme (ACE) inhibitor.
Trandolapril is a prodrug that is deesterified to trandolaprilat. It is believed to exert its antihypertensive effect through the renin-angiotensin-aldosterone system. Trandolapril has a half life of about 6 hours, and trandolaprilat has a half life of about 10. Trandolaprilat has about 8 times the activity of its parent drug. Approximately 1/3 of Trandolapril and its metabolites are excreted in the urine, and about 2/3 of trandolapril and its metabolites are excreted in the feces. Serum protein binding of trandolapril is about 80%.
Patients also on diuretics may experience an excessive reduction of blood pressure after initiation of therapy with trandolapril. Trandolapril can reduce potassium loss caused by thiazide diuretics, and increase serum potassium when used alone. Therefore hyperkalemia is a possible risk. Increased serum lithum levels can occur in patients who are also on lithium.