The information of 1-Isopropylnaphthalene

1-Isopropylnaphthalene (1) was administered orally to rabbits and the afterward eight metabolites, 2-(1-naphthyl)-2-propanol (7), 2-(1-naphthyl)-1-propanol (8: R/S = 83:17), 2-(1-naphthyl)-1,2-propanediol (9:R/S = 40:60), 4-isopropyl-1,2-naphthoquinone (10), 4-isopropyl-1-naphthol (11), 4-isopropyl-2-naphthol (12), 5-isopropyl-2-naphthol (13), and 2-(1-naphthyl)propanoic acerbic (14') as its methyl ester (14: R/S = 52:48), were abandoned from urine. Among them, three metabolites (8, 9, and 14), possessing an agee carbon atom in the molecule, were formed enantioselectively and 5 metabolites (7, 10, 11, 12, and 13) were formed regioselectively. The accepted metabolic pathways of 1-isopropylnaphthalene (1) in rabbits arch to these metabolites are discussed.1-Isopropylnaphthalene (1) was administered orally to rabbits and the afterward eight metabolites, 2-(1-naphthyl)-2-propanol (7), 2-(1-naphthyl)-1-propanol (8: R/S = 83:17), 2-(1-naphthyl)-1,2-propanediol (9:R/S = 40:60), 4-isopropyl-1,2-naphthoquinone (10), 4-isopropyl-1-naphthol (11), 4-isopropyl-2-naphthol (12), 5-isopropyl-2-naphthol (13), and 2-(1-naphthyl)propanoic acerbic (14') as its methyl ester (14: R/S = 52:48), were abandoned from urine. Among them, three metabolites (8, 9, and 14), possessing an agee carbon atom in the molecule, were formed enantioselectively and 5 metabolites (7, 10, 11, 12, and 13) were formed regioselectively. The accepted metabolic pathways of 1-isopropylnaphthalene (1) in rabbits arch to these metabolites are discussed.The rearrangements of chargeless radicals originated from 2-(2-naphthyl)-1-methylethylhydroperoxide and 2-(1-naphthyl)-1-methylethylhydroperoxide, i.e. from the molecules complex in the action of assembly of 2-naphthol from 2-isopropylnaphthalene, were advised application abstract methods (DFT). Moreover, the abstraction was aimed at award origins of inhibition of the action of 2-isopropenyloxynapthalene blaze due to the contagion of raw actual with 1-isopropylnaphthalene (1-IPN). It has been begin that one of the acknowledgment paths involving the barter of a chargeless abolitionist originated from 1-IPN can be amenable for the action of inhibition.
Read more: buy 1-Isopropylnaphthalene