The Introduction of Methoxyfenozide

Methoxyfenozide, (trade name: Runner 2FR, Intrepid 2FR, also known as methicillin tebufenozide, RH-2485) is the U.S. Dow AgroSciences Ltd (Dow AgroSciences LLC) of new pesticide products. Methoxy tebufenozide by the Roma - Haas Company (Rohm-Hass) in 1990 found that, published in 1996. Dow AgroSciences acquired in 2000, Roma - Haas Company and the Ministry of pesticide products, and in 2001 the brand name "happy" in China to obtain temporary registration of pesticides, in December 2005 changed the brand name "Ray-pass" been formally registered. The products are mainly used to control Lepidoptera, Hymenoptera class and other pests, because of its low dose, long-holding effect, stable, efficient, human animal safety features, much peasants. Zhu Limei in 2001, foreign-methoxy-hydrazide in the application, etc. were introduced. In this paper, the insecticidal mechanism through mine, safety, and range of applications in domestic use as an introduction, a reference to its application.
The compound is a white powder, melting point 206.1 ~ 208 ℃, specific gravity of 0.740 ± 0.0081. In the next 25, 35 and 45 ℃ evaporating pressure is less than 1.33 × 10-5 Pa; at room temperature, pH = 5 ~ 9 under the conditions of acid or base-catalyzed reaction is stable, but the melting point and heat release under conditions of concentrated acid of isobutylene and other by-products; LogP and solubility in water were 3.7 and 3.3mg / L. The compound at room temperature in non-polar organic agent of vegetable oil and xylene in low concentration solutions (<10g / L), in polar organic solvents such as cyclohexanone, dimethyl Yan and N-methyl pyrrolidine solubility were 90,110,380 g / L. White liquid formulations, 24% SC, the proportion of 1.06, pH = 6.6, is not flammable, stable at room temperature.
Toxicity and safety
Methoxy tebufenozide the original drug's acute oral, dermal LD50 were> 5000mg/kg; rat acute inhalation LC50> 4.3mg / L. 90d subchronic rat feeding had no effect maximum dose of 1000mg/kg. Ames test, mouse micronucleus test and chromosomal aberration test were negative, non-teratogenic, non-carcinogenic. 24% of its preparation through SC Ray Acute oral LD50> 5000mg/kg, acute dermal LD50> 2000mg/kg; rat acute inhalation LC50 was> 0.9mg / L; on the skin, eyes and non-irritating, non-induced sensitivity. The drug is a low-toxicity insecticides.
Methoxyfenozide the active ingredient is a double-methoxy tebufenozide hydrazide insecticide. For the structure of a non-steroid molting hormones, the natural insect molting hormone analogue - 20 - hydroxy-ecdysone, ecdysone receptor activation and adhesion protein, to promote early before Lepidoptera larvae mature into the molting process but can not form healthy new skin. Resulting in early larvae stop feeding and eventually die.
Methoxyfenozide as a biomimetic hormone insecticides, it's efficient, environmentally friendly, is in line with the requirements of the people of modern pesticides and trends. However, in practice, should pay attention to pest control pest resistance management, it is proposed to use mine through, you can with other agents such as chlorpyrifos, fipronil, divisible and other mix, promote different insecticidal mechanism for alternating pharmaceutical to use.
With highly toxic pesticide residues on awareness-raising and highly toxic pesticides were gradually replaced by hydrazide pesticide status of plant protection in agriculture will gradually increase. Methoxyfenozide is insect growth regulator, its mechanism and the commonly used organophosphorus, carbamates, pyrethroids and other pesticides in different categories. It is not only low toxicity, protect natural enemies, and it is currently difficult to treat agriculture, beet armyworm, diamondback moth, Helicoverpa armigera, leafminer and other significant control effect, drug costs and efficacy is superior to commonly used pesticides. In recent years, Rohm and Haas Company in the country to promote tebufenozide (m full) and the methoxy tebufenozide (happy), m full patent has expired, the domestic manufacturers have been made m full registration of the original drug and formulations , and there is a number of manufacturers, these products will soon be expected to form a new hot spot, methoxy tebufenozide efficacy is tebufenozide 2 to 5 times, especially 3 - methoxy - 2 - methyl benzene formic acid production technology difficult to master, and if we can put into operation as soon as possible to market such products will lead the domestic market.

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