Monday, December 5, 2011

What is N-Methyl-N-nitro-N-nitrosoguanidine

 N-Methyl-N-nitro-N-nitrosoguanidine (MNNG) induction adenoma, adenocarcinoma, a few leiomyosarcoma, and in rat glandular stomach seal ring cell carcinoma. Additional malignant tumor, especially in high concentrations of observation, in the duodenum, jejunum and mesenteric, along with forestomach and liver cancer papilloma. When drinking water management, MNNG induction of leiomyosarcoma, the stomach wall of the cyst, neonatally graft into the subcutaneous tissue in mice. When drinking water management, MNNG induced gastric adenocarcinoma male hamster glands and sarcoma.
In the study of the species used in the digestive tract of the tumors occur spontaneously is thought to be in very rare. When as a single high doses to fill the stomach medicine, composite induction rats glands and forestomach malignant tumors. When the management of a series of irregular stomach irrigation treatment, this compound induce squamous epithelium papilloma and squamous cell carcinoma of the two sexes in forestomach rat glandular stomach, liver and peritoneal tumors. When through the give subcutaneously, adult rats induced by injection parts of the composite fibrosarcoma and pleomorphism sarcoma. In a similar study, fibrosarcoma and leiomyosarcoma male rats induced by injection site. Newborn rat MNNG development adenocarcinoma, fibrosarcoma, and small intestine myosarcomas a single subcutaneous injection. A single subcutaneous injection of lung and liver caused by MNNG tumor and hemangioendotheliomas mice. When intraperitoneal injection to medicine, MNNG induction appendix, the ileum, in male mice jejunum benign and malignant tumors. By a single intraperitoneal injection to medicine, the compounds of induction male rats, and in lactation rats stomach and intestine carcinoma and sarcoma stomach, jejunum and caecum tumor. When rectum perfusion, this compound caused by one or more adenomatous polyps and seven nine rats in the colon and rectum polyp carcinoma. In the IARC working group without censorship, when local, male and female mice induced MNNG skin papilloma and carcinoma recent research.


Read more: N-Methyl-N-nitro-N-nitrosoguanidine for sale

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