The Presentation of Fluperlapine

The antagonists of the subtype (NMDA) glutamate receptor (eg, phencyclidine, ketamine, MK-801) cause a schizophrenic psychosis as in humans and neurotoxicity in the adult rat brain. We report here that agents and structurally related clozapine (olanzapine, fluperlapine, loxapine, amoxapine) can prevent NMDA antagonist neurotoxicity in rats with a rank order corresponding to their ability to mimic the antipsychotic properties of clozapine.
Fluperlapine also known as fluoroperlapine, is an atypical antipsychotic with additional tricyclic antidepressants and sedative effects. It was first synthesized in 1979 and then studied in animals and humans in 1984 and beyond, but still demonstrate efficacy in the treatment of a variety of medical conditions, including schizophrenia, psychosis associated with Parkinson's disease  depressive symptoms, and dystonia, , it was never marketed. This was perhaps due to its production capacity potentially fatal agranulocytosis, even to clozapine,  which it closely resembles both structurally and pharmacologically.
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