Friday, January 24, 2014

Information about Ceftazidime


Ceftazidime is usually reserved for the treatment of infections caused by Pseudomonas aeruginosa. It is also used in the empirical therapy of febrile neutropenia, in combination with other antibiotics. It is usually given IV or IM every 8–12 hours (2 - 3 times a day), with dosage varying by the indication, infection severity, and/or renal function of the recipient.
Ceftazidine is first line treatment for the rare tropical infection, melioidosis.
In addition to the syn-configuration of the imino side chain, compared to other third-generation cephalosporins, the more complex moiety (containing two methyl and a carboxylic acid group) confers extra stability to β-lactamase enzymes produced by many Gram-negative bacteria. The extra stability to β-lactamases increases the activity of ceftazidime against otherwise resistant Gram-negative organisms including Pseudomonas aeruginosa. The charged pyridinium moiety increases water-solubility.

the description of Chymotrypsin


Chymotrypsin is a proteolytic enzyme,which preferentially catalyzes the hydrolysis of peptide bonds involving L-isomers of tyrosine, phenylalanine and tryptophan.The optimum pH is 8.0.The enzyme is inhibited by heavy metals, the natural trypsin inhibitors to various degrees.It is the zymogen form of chymotrypsin. It belongs to the molecular class of serine protease. The molecular weight of Chymotrypsinogen is 25000 Da.Chymotrypsinogen is purified by several crystallization stages, and shows a single band on SDS-PAGE.
Chymotrypsin is synthesized in the pancreas by protein biosynthesis as a precursor called chymotrypsinogen that is enzymatically inactive. On cleavage by trypsin into two parts that are still connected via an S-S bond, cleaved chymotrypsinogen molecules can activate each other by removing two small peptides in a trans-proteolysis. The resulting molecule is active chymotrypsin, a three-polypeptide molecule interconnected via disulfide bonds.
CAS:9004-07-3
Source:Bovine Pancreas
Storage:Preserve in tight containers,and avoid exposure to excessive heat.

Thursday, January 23, 2014

the use of Mupirocin


Mupirocin is an antibiotic cream/ointment which you apply to your skin to treat skin infections. It is used in particular to treat infections caused by meticillin-resistant Staphylococcus aureus (MRSA). It works by killing the bacteria causing the infection. 
Mupirocin, an antibiotic, is used to treat impetigo as well as other skin infections caused by bacteria. It is not effective against fungal or viral infections.This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Mupirocin comes in an ointment that is applied to the skin. Mupirocin usually is applied three times a day for 1 to 2 weeks. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use mupirocin exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.Wash the affected skin area thoroughly, and then gently apply a small amount (a thin film) of the ointment. You may cover the area with a sterile gauze dressing.
CAS : 12650-69-0
Molecular Formula : C26H44O9
Formula Weight : 500.62

the use of Desloratadine


Desloratadine is a drug used to treat allergies. It is marketed under several trade names such as NeoClarityn, Claramax, Clarinex, Larinex, Aerius, Dazit, Azomyr, Deselex and Delot. It is an active metabolite of loratadine, which is also on the market. It has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system.
Desloratadine is  used to treat allergies. Desloratadine is a tricyclic antihistamine, which has a selective and peripheral H1-antagonist action. It is an antagonist at histamine H1 receptors, and an antagonist at all subtypes of the muscarinic acetylcholine receptor. It has a long-lasting effect and in moderate and low doses, does not cause drowsiness because it does not readily enter the central nervous system. Unlike other antihistamines, desloratadine is also effective in relieving nasal congestion, particularly in patients with allergic rhinitis.
Desloratadine is a tricyclic antihistamine, which has a selective and peripheral H1-antagonist action. It is an antagonist at histamine H1 receptors, and an antagonist at all subtypes of the muscarinic acetylcholine receptor. It has a long-lasting effect and in moderate and low doses, does not cause drowsiness because it does not readily enter the central nervous system. Unlike other antihistamines, desloratadine is also effective in relieving nasal congestion, particularly in patients with allergic rhinitis. 
CAS:100643-71-8
Molecular Formula:C19H19ClN2
Molecular Weight:310.82

Wednesday, January 22, 2014

About Shark Cartilage


Shark Cartilage is a premium dietary supplement that provides active cartilage protein for cellular protection. Using no radiation or ethylene oxide.Shark Cartilage Powder is rich in minerals and amino acids.Processing selectively removes unwanted tissue to retain more of the protein-rich soft cartilage that other processing methods may destroy.Each 6-gram scoop provides approximately 3 grams active cartilage protein.
Proponents of shark cartilage are encouraged by anecdotal evidence from users as to its efficacy. The proponents also cite studies that show that shark cartilage has had some success in preventing angiogenesis, the growth of new blood vessels from pre-existing vessels. While angiogenesis is often a normal function, it is also consistent with the growth of malignant tumors. They argue too, that very little research (in the quantity and quality of studies) has been conducted, and thus the benefits cannot be scientifically disputed.
Opponents cite existing studies of shark cartilage on a variety of cancers that produced negligible to non-existent results in the prevention or treatment of cancer. Most notable among these was a breast-cancer trial conducted by the Mayo Clinic that stated that the trial "was unable to demonstrate any suggestion of efficacy for this shark cartilage product in patients with advanced cancer." The results of another clinical trial were presented at the 43rd annual meeting of the American Society for Clinical Oncology. In that study (sponsored by the National Cancer Institute), "researchers did not find a statistical difference in survival" between patients receiving shark cartilage and those taking a placebo. Scientific evidence does not support the efficacy of Shark Cartilage nor the ability of effective components to remove cancer cells. The fact that people believe eating shark cartilage can cure cancer shows the serious potential impacts of pseudoscience.

Detail information about GHRP-2 Acetate

CAS No. 158861-67-7
Molecular Formula C45H55N9O6
Molecular Weight 817.97
Storage 2~8℃
Batch No. 20071220
Manufacturing Date 2007-12-21
Retest Date 2007-12-21
Sequence D-Ala-D-β-Nal-Ala-Trp-D-Phe-Lys-NH2

1Assay95.0~105.0%97.0%
2AppearanceWhite powderWhite powder
3SolubilitySoluble in water or acetic acid to give a clear, colorless solutionConforms
4Amino Acid Composition±10% of theoreticalConforms
5Peptide Purity (By HPLC)>95.0% by area integration97.0%
6Related Substance(By HPLC)Total Impurities(%) <5.0% Largest Single Impurity(%)<1.0%3.0% 0.5%
7Acetate Content (By HPLC)<15.0%13.5%
8Water Content (Karl Fischer)<8.0%2.0%
9Bacterial Endotoxins<5EU/mgConform
10Peptide Content(By N determination)>80.0%83.8%
More about  GHRP-2 Acetate

Tuesday, January 21, 2014

About (R)-(-)-MANDELIC ACID


Mandelic acid is an aromatic alpha hydroxy acid with the molecular formula C6H5CH(OH)CO2H. It is a white crystalline solid that is soluble in water and polar organic solvents. It is a useful precursor to various drugs. Since the molecule is chiral, it exists in either of two enantiomers as well as the racemic mixture, known as paramandelic acid.
Mandelic acid has a long history of use in the medical community as an antibacterial, particularly in the treatment of urinary tract infections. It has also been used as an oral antibiotic, and as a component of 'chemical face peels', along with other alpha-hydroxy acids (AHAs).
The drugs cyclandelate and homatropine are esters of mandelic acid.

Product name:(R)-(-)-Mandelic acid
CAS:611-71-2
Molecular formula:C8H8O3
Molecular weight:152.15